Nanostructured lipid carriers of cefixime trihydrate were prepared by hot melt micro emulsification method. The hot melt was prepared by heating the drug with a blend of solid lipid and liquid lipids: oleic and paraffin wax /bees wax is used as solid lipid and liquid lipids. FTIR studies of pure drug and formulations showed there was no significant change in the signal peaks of drugs; this indicates that there were no interactions between the drug and the formulation excipients. The optimized formulations were characterized for particle size, in-vitro release, entrapment efficiency, drug content and stability studies. The particle size analysis by nano zeta sizer showed that the average particle size of the cefixime trihydrate is 350.7 nm. The PDI value 0.500 indicated good dispersion of uniformly sized NLCâ??s. Comparison of entrapment efficiency and drug release of various formulations established that the NLC prepared with paraffin wax showed significantly higher entrapment efficiency and prolonged drug release compared to the NLC prepared with beeswax. The drug release studies show initial bust release at 67.28 % at the end of 360 min. This indicated that incorporation of cefixime trihydrate into NLC sustained the drug release. The stability studies indicated that formulations stored at refrigeration temperature and room temperature showed no significant drug loss and no significant changes in the drug release pattern, after a period of 4 weeks.
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